Disease: Non-Small Cell Lung Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation disease CGI
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 GeneticVariation disease CLINVAR Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis. 15046639 2004
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 GeneticVariation disease CLINVAR MC1R variants increase risk of melanomas harboring BRAF mutations. 18368129 2008
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation disease CLINVAR Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma. 21190184 2011
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation disease CLINVAR A structural systems biology approach for quantifying the systemic consequences of missense mutations in proteins. 23093928 2012
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation disease CLINVAR Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma. 22535154 2012
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation disease CLINVAR Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma. 21343559 2011
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 GeneticVariation disease CLINVAR Mutations of the BRAF gene in human cancer. 12068308 2002
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation disease CLINVAR Missense mutations of the BRAF gene in human lung adenocarcinoma. 12460919 2002
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 GeneticVariation disease CLINVAR KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy. 19913317 2010
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation disease CLINVAR Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum. 19206169 2009
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation disease CLINVAR Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines. 19593635 2010
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation disease CLINVAR BRAF, p53 and SOX2 in anaplastic thyroid carcinoma: evidence for multistep carcinogenesis. 21716161 2011
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation disease CLINVAR Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas. 14688025 2004
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation disease CLINVAR Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma. 19794125 2009
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 GeneticVariation disease CLINVAR Activating BRAF and N-Ras mutations in sporadic primary melanomas: an inverse association with allelic loss on chromosome 9. 14681681 2003
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation disease CLINVAR Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. 15035987 2004
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 GeneticVariation disease CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation disease CLINVAR Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma. 19363522 2009
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 GeneticVariation disease CLINVAR B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis. 17311103 2007
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation disease CLINVAR Phosphatidylinositol-3-OH kinase or RAS pathway mutations in human breast cancer cell lines. 17314276 2007
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 GeneticVariation disease CLINVAR Inactivation of the mitogen-activated protein kinase pathway as a potential target-based therapy in ovarian serous tumors with KRAS or BRAF mutations. 15753399 2005
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation disease CLINVAR The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway. 22892241 2012
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 GeneticVariation disease CLINVAR High frequency of mutations of the PIK3CA gene in human cancers. 15016963 2004
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 GeneticVariation disease CLINVAR Gene expression signature associated with BRAF mutations in human primary cutaneous melanomas. 19383316 2008